Tumor Immune Syngeneic MOuse (TISMO) is a database specifically designed for hosting, visualizing, and analyzing an extensive collection of syngeneic mouse model data. We uniformly processed raw sequencing data for 1,525 mouse samples, covering 68 cell lines and 19 cancer types, to generate gene expression and immune cell infiltration profiles, of which 448 samples underwent immune checkpoint blockade (ICB) treatment. In addition, TISMO hosts 600 in vitro samples of which 195 were cytokine treated. Sample metadata, including cancer type, cell line, mouse strain, transplantation site, ICB treatment, and response status were manually curated. TISMO provides interactive interfaces for users to explore gene expression and immune infiltration, and allows systematic comparisons between different model characteristics, and treatment and response groups.Get started by exploring:
TISMO | © X Shirley Liu Lab 2021 | Dana Farber Cancer Institute
An overview of the syngeneic mouse model data in the TISMO database. In total, 2,125 samples covering 86 different cell lines and 25 cancer types are included. The ‘ICB Treatment’ tab summarizes tumor samples treated with immune-checkpoint blockade such as anti-PD1, anti-PDL1, anti-PDL2, antiCTLA4, and anti-CTLA4 + anti-PD1/L1 combinations. The ‘Cytokine Treatment’ tab summarizes in vitro tumor lines treated with cytokines such as interferon γ (IFNγ), IFNβ, tumor necrosis factor alpha (TNFα) and transforming growth factor (TNFβ). The ‘Baseline’ tab summarizes in vivo and in vitro samples used as study controls (e.g. untreated, isotype or vehicle treated).